Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate

	Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate
	Sun, T. T.; X. G. Guan; M. Zheng; X. B. Jing and Z. G. Xie
	2015
发表期刊	Acs Medicinal Chemistry Letters
卷号	6 期号:4 页码:430-433
摘要	A convenient synthesis of a BODIPY (1,3,5,7-tetramethyl-8-(4-pyridyl)-4,4'-difluoroboradiazaindacene) labeled platinum compound (BODIPY-Pt) was developed by direct conjugation of cisplatin with the pyridine group of BODIPY. The membrane permeability and selective uptake of BODIPY-Pt in the mitochondria was studied using confocal laser scanning microscopy (CLSM). The fluorescent BODIPY-Pt conjugate showed high cellular proliferation inhibition against human cervical carcinoma (HeLa) and human breast cancer (MCF-7) cells, with half maximal inhibitory concentrations (IC50) of 27.37 and 12.14 mu M, respectively. This work highlights the potential of using BODIPY labeled Pt compounds to realize the visualization of Pt distribution in living cells.
收录类别	SCI
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/55411
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Sun, T. T.,X. G. Guan,M. Zheng,et al. Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate[J]. Acs Medicinal Chemistry Letters,2015,6(4):430-433.
APA	Sun, T. T.,X. G. Guan,M. Zheng,&X. B. Jing and Z. G. Xie.(2015).Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate.Acs Medicinal Chemistry Letters,6(4),430-433.
MLA	Sun, T. T.,et al."Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate".Acs Medicinal Chemistry Letters 6.4(2015):430-433.

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